The epistemological transition redefining clinical oncology departs from a purely tumor-centric vision—focused solely on the genomic alterations of the neoplastic cell—to embrace an ecological and systemic paradigm. At the core of this conceptual revolution lies the tumor microenvironment, a complex and dynamic ecosystem in which malignant cells coexist and communicate with stromal components, infiltrated immune cells, blood vessels, and a remod…
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