Restoring Inhibitory Neuron Plasticity May Reverse Neurodevelopmental Disorder Symptoms, Preclinical Study Suggests

Restoring inhibitory neuron plasticity may reverse neurodevelopmental disorder symptoms, preclinical study suggests

Some of the symptoms of neurodevelopmental disorders (NDDs), such as autism spectrum disorder and epilepsy, may result from dysfunction of certain neurons in the brain and their ability to change their properties in response to experiences—a process called experience-dependent plasticity. In preclinical research published in Nature, a team led by investigators at Mass General Brigham identified genes involved in these neurons' plasticity and the…

Targeting single gene reverses developmental deficits in adult mice

Some of the symptoms of neurodevelopmental disorders (NDDs) such as autism spectrum disorder and epilepsy may result from dysfunction of certain neurons in the brain and their ability to change their properties in response to experiences-a process called experience-dependent plasticity.

Adult Brains May Retain a Treatment Window in Autism

A common assumption about developmental brain conditions is that treatment must happen very early, before the brain finishes its major stages of development. A new laboratory study challenges that idea by showing that a disrupted brain signal could still be improved in adult mice. The research comes from the Institute for Basic Science in South […] The post Adult Brains May Retain a Treatment Window in Autism appeared first on Knowridge Science …

Neurodevelopmental conditions may share faulty plasticity

Restoring an experience-dependent interneuron plasticity gene in adulthood improves memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.