Scientists solve the mystery of a brain “switch” that can trigger weight loss in opposite ways
3 Articles
3 Articles
Scientists solve the mystery of a brain “switch” that can trigger weight loss in opposite ways
Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor in the brainstem reduced appetite, while blocking it in the hypothalamus removed a kind of “brake” on fullness signals. The discovery helps explain why very different obesity drugs can achieve similar results and suggests that carefully combining GIP-targeting treatments with GLP-1 drug…
Study in mice shows how to activate or block the same receptor can potentiate weight loss
Researchers at the University of Cambridge investigated the mechanisms of action of the GIP (glucose-dependent insulinotropic polypeptide) receptor and discovered how activation and blockade of this receptor in the brain can promote weight loss in distinct ways. The study, published in the journal Nature Metabolism, reveals the importance of the brain regions involved in this process. Mechanisms of action of the GIP receptor The researchers iden…
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