Placental transport mechanism could guide safer biologic medicines during pregnancy

Placental biology breakthrough could make biologic medicines safer during pregnancy

Biologic medicines have transformed the treatment of cancer, autoimmune diseases, migraine, inflammatory disorders and many other diseases.

Placental transport mechanism could guide safer biologic medicines during pregnancy

Biologic medicines have transformed the treatment of cancer, autoimmune diseases, migraine, inflammatory disorders and many other conditions. Yet their growing use among women of reproductive age constitutes a major clinical challenge because therapeutic IgG antibodies are actively transported across the placenta to the developing fetus. Evidence supporting the safe use of such therapeutics during pregnancy remains limited.

Placental albumin barrier enables long-acting biologics with reduced fetal

Biologic medicines have transformed care for cancer, autoimmune disease, migraine, inflammatory disorders and numerous other conditions. Yet their expanding use among women of reproductive age has created a difficult clinical problem: many of these medicines are therapeutic immunoglobulin G (IgG) antibodies, and IgG can be actively transported across the placenta to the developing fetus. Because evidence on the safety of biologic treatment durin…