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Moderna Stock Plunges 25%—Wiping Out $18 Billion After Historic Cancer Vaccine Breakthrough

The pullback erased much of Wednesday’s 177% surge as traders waited for full trial data and a broader read-through to other cancers.

  • Moderna shares dropped 20% on Thursday, reversing part of Wednesday's historic 177% rally after a volatile two-day trading session.
  • The volatility followed Wednesday's announcement that Moderna and Merck's personalized mRNA cancer vaccine, intismeran autogene, hit its primary endpoint in the Phase 3 INTerpath-001 trial.
  • JPMorgan analyst Jessica Fye noted "success in adj melanoma as priced in with the stock sitting at ~$25bn market cap prior to the news," explaining the reversal.
  • Broader biotech markets also reacted, as BioNTech shares fell 4% and the Biotechnology ETF dropped 2%, while Merck shares slipped only 1%.
  • Complete trial data due at the ESMO conference in Madrid from October 23 to 27 will determine whether the melanoma win extends to other tumor types.
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22 Articles

Lean Right

According to Moderna's price jump, these four pharma and biotech shares could be particularly strongly moved by important study data.

·Berlin, Germany
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Lean Right

The Moderna share increased by 177 percent on Wednesday. The reason is the breakthrough in an active ingredient. How often are such price jumps in just one day? And is this justified?

·Vienna, Austria
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Hospodářské Nnoviny (HN.cz) broke the news on Wednesday, August 19, 2026.
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