Breaking and Entering: How Parasites Prepare Host Cells for Invasion
Researchers found that disrupting host cholesterol or sugar pathways reduced rhoptry discharge and impaired invasion, revealing how Toxoplasma senses the right cell to enter.
5 Articles
5 Articles
Breaking and entering: How parasites prepare host cells for invasion
Before the parasite Toxoplasma gondii can invade a cell, it has to know it has reached the right place. New research from the Whitehead Institute reveals that the parasite doesn't simply recognize a ready-made doorway into the cell. Instead, it helps create the conditions for its own entry.
Toxoplasma gondii uses the surface of its host cells not only as a docking site. Experiments show that the parasite pulls sugar-bearing proteins together in cholesterol-dependent membrane areas and thus prepares a decisive step of its invasion. If this conversion is disrupted, the parasites release less rhoptrien content and penetrate more rarely into cells. Cambridge (U.S.A.). To get into a host cell [...] The post So prepare parasite host cell…
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