3D Co-Culture Model of Tumor Spheroid and Endothelial Cells Unveils ccRCC Aberrant Vasculature and Distinct Sensitivity to Targeted Treatments
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The tumor microenvironment and integrated cellular medicine: the new frontier in precision oncology
The epistemological transition redefining clinical oncology departs from a purely tumor-centric vision—focused solely on the genomic alterations of the neoplastic cell—to embrace an ecological and systemic paradigm. At the core of this conceptual revolution lies the tumor microenvironment, a complex and dynamic ecosystem in which malignant cells coexist and communicate with stromal components, infiltrated immune cells, blood vessels, and a remod…
3D Co-Culture Model of Tumor Spheroid and Endothelial Cells Unveils ccRCC Aberrant Vasculature and Distinct Sensitivity to Targeted Treatments
The authors investigated the 3D architecture of clear cell renal cell carcinoma (ccRCC) vasculature within the tumor microenvironment and its response to drugs. They defined key features and heterogeneity of ccRCC vascular architecture and highlighted ponds as candidate contributors to treatment failure and targets for future interventions. [Angiogenesis] Abstract
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