US EditionUterine Fibroids Linked To Women's Heart Disease Risk
Women with uterine fibroids face over 80% higher long-term risk of cardiovascular disease and younger women under 40 have a 251% increased risk, study shows.
- Published December 10, 2025, the study found women diagnosed with uterine fibroids had more than 80% higher long-term heart disease risk, according to the research.
- Researchers note uterine fibroids and cardiovascular disease share biological pathways including smooth muscle growth, fibrous buildup, calcification and inflammation, yet fibroids remain understudied and poorly understood.
- Using nationwide records from 2000–2022, researchers analyzed more than 450,000 women with fibroids versus 2.2 million without, finding 5.4% versus 3% had cardiovascular events at 10 years and a 251% higher risk for women under age 40.
- Clinicians say well‑woman visits offer chances to address cardiovascular risk, and the American Heart Association advised women with fibroids to discuss heart health while researchers call for more study before guideline changes.
- Given prevalence, nearly 26 million pre‑menopausal U.S. women have fibroids, and the study suggests fibroids may serve as a marker for elevated cardiovascular risk up to 10 years.
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21 Articles
Watauga Democrat
Uterine Fibroids Linked To Women's Heart Disease Risk
Key Takeaways
A broad study, conducted in almost 3 million women, shows that the diagnosis of uterine fibrom is associated with a higher risk of developing long-term cardiovascular diseases, especially in young women. This relationship has been observed in all racial and ethnic groups. Women with uterine fibroams would [...]
New Study Links Uterine Fibroids With Greater Odds of Heart Disease
As many as 1 in 5 women may have uterine fibroids during their childbearing years — and those abnormal growths may have a connection not just to reproductive health but also to heart health.e60dc2a1-f33c-4a05-9b50-8e3e8e597629b503b626-77da-4056-9892-3b8275ecc935 According to a new study, women with fibroids had an 81 percent higher risk of developing long-term heart disease than those without the fibroid diagnosis.e60dc2a1-f33c-4a05-9b50-8e3e8e5…
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