UCLA researchers develop scalable TCR therapy for solid tumors

UCLA researchers develop scalable TCR therapy for solid tumors

T cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision. It's similar to another treatment, CAR T-cell therapy, but with one key difference: CAR T-cell therapy can only spot proteins that naturally appear outside of a cancer cell.

Scientists engineer ready-to-use cancer-fighting T cells for solid tumors

T-cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision. It's similar to another treatment, CAR T-cell therapy, but with one key difference: CAR T-cell therapy can only spot proteins that naturally appear outside a cancer cell. TCR therapy, however, can also catch small protein fragments from inside the cell that are carried to the surface and displayed like little name tags.

UCLA Scientists Engineer Ready-to-Use Cancer-Fighting T Cells for Solid Tumors

UCLA researchers have developed a way to mass-produce cancer-fighting T cells from blood stem cells found in cord blood, engineered to target a protein found in many solid tumors -- creating uniform batches instead of custom treatments for each patient.