Denver Broncos at San Francisco 49ers: TV Channel, Time, What to Know

Broncos vs. 49ers prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

Denver Broncos vs. San Francisco 49ers – October 4, 2026 Betting Preview

Denver Broncos at San Francisco 49ers: TV channel, time, what to know

Here's everything to know about the Broncos' Week 4 game against the 49ers.

The Matchups That Will Decide 49ers Broncos

49ers vs. Broncos is a classic strength-on-strength matchup — and this game could come down to which team can force the other out of its comfort zone. In this preview, we break down the biggest matchups San Francisco has to solve on both sides of the ball. How should Kyle Shanahan attack Denver’s defense? What can the 49ers do to create favorable looks for Brock Purdy and Christian McCaffrey? And on defense, what does San Francisco need to take …

Broncos vs. 49ers preview

Here's everything you need to know about the Week 4 matchup between the Denver Broncos and the San Francisco 49ers during the 2026 NFL season.