Targeted mRNA Nanoparticles Turn Tumor Macrophages Against Cancer
The approach reduced immunosuppressive macrophages by more than 60% and increased CXCL9 levels fourfold in mice with 4T1 breast tumors.
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5 Articles
Immunotherapy often fails with solid tumors because defence cells hardly get into the tumor tissue. In mice, mRNA nanoparticles targeted at tumor macrophages have partially solved this immune brake: They reduced suppressive macrophages, increased the lock molecule CXCL9 and brought more cancer-fighting T cells into the tumor. Adelaide (Australia). Many tumors build a kind of protective space from body immune cells. Especially [...] The post "Sma…
Smart Nanoparticles Reprogram Tumour Defenses to Boost Immune Attack on
Scientists at Adelaide University have unveiled a new mRNA-based strategy that could reshape one of the most stubborn obstacles in cancer treatment: the hostile environment that tumours build around themselves to keep the immune system at bay. In a study published in Science Advances, a multidisciplinary team spanning chemical engineering, biomedical science, oncology and immunology […]
New ‘Smart’ Nanoparticles Help the Immune System Better Attack Tumours
The same technology used to deliver mRNA in COVID-19 vaccines is being used to target a type of immune cell that can help tumours evade the body's defences. Adelaide University researchers have effectively reprogrammed these cells so they can do their job and fight cancer.
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