Stanford Transplants Lab-Grown Human Brain Tissue into Mice
The grafts grew for months, formed functional connections and produced human cell types not normally found in mice, researchers said.
- On Wednesday, Stanford University neuroscientists published a study in Nature describing a new method for growing human brain organoids inside genetically engineered mice.
- Previous attempts failed because rodent cells outcompeted human grafts; neuroscientist Sergiu Pașca and his Stanford University team solved this by engineering mice lacking specific cerebral cortex and hippocampus structures.
- In 25 of 29 attempts, human tissue filled more than 90% of the vacant space, forming specialized neurons including rare von Economo cells never before grown in a dish.
- These chimeric animals provide a platform to study cerebral palsy and frontotemporal dementia; Pașca noted human cortical cells appear to restore lost functions in the grafted mice.
- Experts like Nita Farahany of Duke Law emphasize ethical caution as the team deliberately halted experiments before human cells formed consciousness markers, noting this work "brings us into new gray areas.
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In a U.S. laboratory, the cerebral brain of mice with bred "mini brains" was replaced from human cells. What it brings is still unclear. Ethically, some dust is stirred up for this.
Stanford University researchers have replaced a large portion of a mouse brain with lab-grown human tissue, overcoming a space constraint that has long hampered brain organoid transplantation. The new method will allow researchers to study human brain development and disease in a living, mobile organism.
US scientists have transplanted human brain tissue produced in the laboratory into mice genetically engineered so that the cerebral cortex does not develop in much of their brains. The study, which shows that human cells become functional by binding to the nervous system of mice, could create a new model for the study of neurodevelopmental diseases such as autism, epilepsy and cerebral palsy.
Hybrid human-mouse brain created in landmark lab experiment
A landmark experiment led by Stanford University researchers expands the scope of what we can learn from lab-grown neural models, dramatically improving the integration of a human cortical organoid with another animal's nervous system.Continue ReadingCategory: Imaging & Diagnostics, Medical Innovations, Body and MindTags: Brain, organoid, Mice, xenotransplant, Cortex, Transplant, Stanford University
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Cedarnews.net. لمتابعة المزيد من أخبار والتقارير الحصرية، زورونا على موقعنا. US neuroscientists have successfully made mice have functional human cells within their own brains. This is Cedarnews. للاطلاع على مزيد من الأخبار العاجلة والتقارير الحصرية، زوروا موقعنا الرسمي.
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