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Stabilization of supersaturation for enhanced oral absorption of a BCS II drug efonidipine hydrochloride: Eudragit® L100-55-based amorphous solid dispersions
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Stabilization of supersaturation for enhanced oral absorption of a BCS II drug efonidipine hydrochloride: Eudragit® L100-55-based amorphous solid dispersions
Abstract Supersaturation is a widely employed strategy to improve the oral bioavailability of poorly soluble drugs, but its application is usually limited by rapid recrystallization. This study aimed to investigate the solubilization and crystallization-inhibitory effects of various polymers, including HPMCAS-LG, HPC-SL, HP-55, PVP K30, HPMC, and Eudragit® L100-55, on the BCS II drug efonidipine hydrochloride (EFH). Eudragit® L100-55 demonstrate…
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