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49ers vs. Rams Predictions, Picks and Best Bets for NFL Thursday Night Football: NFC West Rivalry in Primetime

The Rams enter as 6-0 straight up and 5-1 against the spread as heavy favorites, facing a 49ers team fielding a bottom-three NFL roster this week.

Summary by The Oregonian
The Los Angeles Rams have won three straight games against the San Francisco 49ers, finally throwing some cold water on the narrative that 49ers coach Kyle Shanahan owns Rams coach Sean McVay. To be fair, there was a stretch from 2019 to 2023 when the 49ers went 9-0 against the Rams in the regular season. In McVay’s defense, he did win the lone playoff game between the two.
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USA Today broke the news in United States on Thursday, October 2, 2025.
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