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Harmful Tau Spreads Like Self-Propagating Prion Proteins

The seeded mouse tau matched human Alzheimer’s and CBD structures, and the two folds produced different patterns of brain pathology.

Summary by Nature
Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-02778-wStructural studies support the idea that fibrillized tau protein, a feature of neurodegenerative disorders, acts as a prion-like template to induce misfolding in healthy tau.

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A fundamental study shows that unfolded tau protein transfers its specific molecular structure to the body's own proteins and generates disease-specific damage patterns in the brain.

·Kassel, Germany
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Nature broke the news in London, United Kingdom on Wednesday, September 30, 2026.
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