Researchers Find Unexpected Protein Regulator of Leukemia Drug Sensitivity

Researchers find unexpected protein regulator of leukemia drug sensitivity

How cells respond to the leukemia drug 6-thioguanine still holds surprises: A new study, led by researchers from CeMM and the University of Oxford identifies NUDT5 as an unexpected regulator of drug sensitivity and reveals that its role has nothing to do with its enzymatic activity.

Researchers uncover new control mechanism for decades-old leukemia drug

image: Degradation of NUDT5 (Artistic representation, © Tuan-Anh Nguyen / Wolfgang Däuble) view more  Credit: © Tuan-Anh Nguyen / Wolfgang Däuble (Vienna, 12 August 2026) For more than 70 years, the drug 6-thioguanine (6-TG) has been used to treat leukemia. Although its clinical effects have been studied extensively, scientists are still uncovering the molecular mechanisms that […]