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Rams vs 49ers Odds, Matchup, and Picks for NFL Matchup in Australia

The Rams are favored after major offseason additions, but San Francisco’s healthier roster and strong offensive core could keep the game close.

  • The San Francisco 49ers and Los Angeles Rams kick off their 2026 season Thursday at the Melbourne Cricket Ground, marking the NFL's first-ever regular-season game in Australia.
  • San Francisco arrived roughly a week early to acclimate to the time zone, while Los Angeles opted for a shorter timeline, spending over 15 hours on a plane to maintain Pacific Time operations.
  • Los Angeles added reigning Defensive Player of the Year Myles Garrett, while San Francisco welcomes back Nick Bosa and debuts receiver Mike Evans alongside quarterback Brock Purdy.
  • Dimers simulations favor the Rams with a 62.9% win probability compared with 37.1% for San Francisco, while sportsbooks set the spread at-3.5 for NFC West rivals.
  • Both franchises enter as Super Bowl favorites seeking a crucial division win to open their campaigns, with the matchup carrying historic significance as the league's Australian debut.
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The match 49ers vs. Rams EN VIVO takes the NFL to Melbourne with two teams that arrive at the first game of the season with different preparation strategies.

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NBC Sports broke the news in Stamford, United States on Wednesday, September 9, 2026.
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