Psychedelics may be no better than antidepressants for depression
A UCSF meta-analysis of 24 trials found psychedelics and traditional antidepressants lowered depression scores by 12 points with no significant difference in effectiveness.
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7 Articles
Psilocybin, a miracle medicine? The most comprehensive German study to date now shows that even psychedelic drugs can't help everyone – but some can.
Psychedelics may be no better than antidepressants for depression
Drugs like psilocybin that induce psychedelic effects have shown promise for treating depression. Now, a review of the evidence suggests that they are effective, but no more so than traditional antidepressants
Are Psychedelic Drugs More Effective Than Antidepressants?
Recent years have seen a surge of interest in psychedelic-assisted therapy as a potential breakthrough treatment for depression. Substances like psilocybin, commonly known as “magic mushrooms,” and LSD have been explored for their potential to help individuals who don’t respond well to traditional antidepressants. Early research indicated significant benefits, fueling excitement among scientists, healthcare providers, and the public alike. Howev…
Psychedelics vs. Antidepressants: Are They Equally Effective for Treating Depression?
Scanning Electron Microscopy of Magic Mushroom Spores Ted Kinsman/Science Photo Library Psychedelic substances like psilocybin, LSD, and DMT are being explored as potential treatments for depression, but research suggests they may not be as effective as traditional antidepressants. Despite the promising results, the challenge remains: many participants in these studies can identify if they received [...] The post Psychedelics vs. Antidepressants…
Mannheim/Berlin – A randomized, triple-blind, phase 2b trial from Germany provides evidence for a possible antidepressant effect of psilocybin in treatment-resistant depression – however, the primary endpoint was not met (JAMA Psychiatry 2026; DOI: 10.1001/jamapsychiatry.2026.0132). The study was conducted at the Central Institute for...
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