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Protective mechanism discovered in female brain: Switched-off X chromosome can reactivate to reduce disease severity

Summary by Medical Xpress
Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have identified a mechanism that protects the female brain from genetic diseases. Although one of the two X chromosomes is switched off in female cells at an early stage, cells reactivate selected genes on this chromosome. This results in weaker symptoms of disease.

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Protective mechanism discovered in female brain: Switched-off X chromosome can reactivate to reduce disease severity

Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have identified a mechanism that protects the female brain from genetic diseases. Although one of the two X chromosomes is switched off in female cells at an early stage, cells reactivate selected genes on this chromosome. This results in weaker symptoms of disease.

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Medical Xpress broke the news in on Monday, February 2, 2026.
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