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Bills vs. Rams Prediction, Odds, Spread, Injuries, Trends for NFL Week 5

Pro Picks cited Buffalo’s seven giveaways in two games and called the Rams a 2 1/2-point favorite in a close home win.

  • On Monday, October 12, the Los Angeles Rams host the Buffalo Bills at SoFi Stadium in a prime-time matchup billed as a "Super Bowl preview."
  • The Rams enter at 2-2 following a 24-20 comeback victory over the Philadelphia Eagles last Sunday, while the Bills hold a 3-1 record but are coming off a 29-26 loss to the New England Patriots.
  • DraftKings Sportsbook lists the Rams as 2.5-point favorites with a 54.5 total; Dimers projects a 60.6% win probability for Los Angeles while ESPN Analytics gives the Bills a 40.3% chance.
  • Buffalo must address turnover issues after seven giveaways in the past two games against a Rams defense ranking third in opponent EPA per play.
  • Despite missing Myles Garrett, the Rams maintain a top-10 run defense in what analysts expect to be a high-scoring "Super Bowl preview.
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14 Articles

The Washington PostThe Washington Post
+10 Reposted by 10 other sources
Lean Left

Pro Picks: Rams will edge the Bills on Monday night in potential Super Bowl preview

·Washington, United States
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Bias Distribution

  • 50% of the sources lean Left, 50% of the sources are Center
50% Center

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Democrat & Chronicle broke the news in Rochester, United States on Tuesday, October 6, 2026.
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