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Pfizer’s Ultra-Long-Acting Injectable GLP-1 RA Shows Robust and Continued Weight Loss with Monthly Dosing in Phase 2b Trial
- On Tuesday, Pfizer Inc. shared topline VESPER-3 Phase 2b results showing PF'3944 produced up to 12.3% mean placebo-adjusted weight loss at week 28 in adults with obesity or overweight without type 2 diabetes.
- Soon after the Metsera acquisition closed, Pfizer added PF'3944 via a $10 billion deal and is pursuing monthly dosing to improve adherence in its obesity portfolio.
- The 64-week study randomized VESPER-3 participants to weekly induction then monthly maintenance, testing four dosing regimens that all outperformed placebo at week 28 with mild or moderate side effects and nearly 10% discontinuations.
- Pfizer plans to advance ten Phase 3 trials with PF'3944 in 2026 and will test a pivotal 9.6 mg high monthly dose later this year, while investors pushed shares down as analysts compared results with rivals.
- PF'3944's long half-life positions it differently from weekly GLP-1s, with Pfizer targeting potential approvals starting in 2028 and pursuing combination strategies despite competition from Eli Lilly and Novo Nordisk.
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Data for Pfizer’s Monthly Injectable GLP-1 Drug Pave Way for Broad Phase 3 Plan in Obesity
A monthly injectable GLP-1 drug from Pfizer’s $10 billion Metsera acquisition is now on track for a Phase 3 program spanning 10 pivotal studies this year. While Pfizer’s pipeline spans internally developed and in-licensed assets for other targets, the pharma company says the Metsera drug is the foundation for its obesity strategy pursuing monotherapies and combination treatments. The post Data for Pfizer’s Monthly Injectable GLP-1 Drug Pave Way …
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Total News Sources17
Leaning Left2Leaning Right0Center6Last UpdatedBias Distribution75% Center
Bias Distribution
- 75% of the sources are Center
75% Center
L 25%
C 75%
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