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The 49ers Host the Titans in Search of Their First 4-Game Winning Streak Since 2023

Christian McCaffrey was limited in practice due to illness but is expected to play Sunday; he ranks fifth in NFL receptions with 1,655 yards and 13 touchdowns, sources say.

  • On Sunday, December 14 the San Francisco 49ers host the Tennessee Titans at Levi's Stadium, with Brock Purdy, Christian McCaffrey and George Kittle healthy and leading the offense.
  • Thursday's practice showed Christian McCaffrey limited by illness, which reporters described as not related to a new leg injury.
  • Through 13 games Christian McCaffrey, San Francisco 49ers running back, has 237 carries, 85 catches and 13 total touchdowns; if limited Sunday, Brian Robinson Jr. would be next up while San Francisco could shift to short‑game and passing designs.
  • The 49ers will issue a game-status report on Friday, clarifying Christian McCaffrey's designation as fans and fantasy managers searched injury updates ahead of Week 15 against the 2-11 Tennessee Titans.
  • McCaffrey's 2024 injury history shows he missed time with calf, Achilles, knee, and a PCL injury requiring injured reserve, and given his heavy workload, conditioning and energy remain the bigger concern while the 49ers win despite depth and defensive absences.
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Patriots and Broncos are both home underdogs despite 10-game winning streaks

The AFC’s two top teams are home underdogs in Week 15. That sums up the state of the NFL in 2025. There are no dominant teams and even the ones with the best records still have much to prove.

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Associated Press News broke the news in United States on Wednesday, December 10, 2025.
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