Overlooked ubiquitin precursor promotes cellular stress resistance and longevity

Overlooked ubiquitin precursor promotes cellular stress resistance and longevity

Researchers from the University of Cologne and Heinrich Heine University Düsseldorf have identified a new ubiquitin form dedicated to proteostasis and healthy aging. They show that CxUb (C-terminally extended ubiquitin), is necessary and sufficient to overcome stress, a discovery that opens up new routes for the treatment of cancer and aging-related diseases.