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Oral semaglutide fails to slow early Alzheimer’s decline in two phase 3 trials

Summary by News Medical
Two large phase 3 trials found that oral semaglutide 14 mg did not slow cognitive or functional decline over 104 weeks in people with early symptomatic, amyloid-positive Alzheimer’s disease. Semaglutide was generally consistent with its known safety profile and showed some biomarker changes, but these did not translate into clinical benefit.

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News Medical broke the news in United States on Monday, March 23, 2026.
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