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NHS rolls out ovarian cancer test for women with ‘Angelina Jolie gene’

The Roca test halves late-stage ovarian cancer diagnoses by monitoring CA 125 protein levels and genetic risks for women with BRCA mutations, improving early detection and care.

  • University College London Hospitals NHS Foundation Trust has become the first in England to offer the risk of ovarian cancer algorithm test, working with NHS North Central London Cancer Alliance and GENinCode Plc.
  • Women with BRCA1 or BRCA2 gene variants have lifetime ovarian cancer risks of 44% and 17%, and NHS guidelines recommend removing ovaries and fallopian tubes to reduce risk.
  • The Roca test calculates a woman's individual risk by analyzing cancer antigen 125 trends, age, menopausal status and BRCA status, and studies show testing every four months halves late-stage diagnoses.
  • Detecting cancers when smaller allows less extensive surgery, and four-month testing can help women at inherited risk of ovarian cancer delay preventive surgery to remove ovaries and fallopian tubes until after menopause.
  • There hasn't so far been an organised surveillance programme for women at inherited risk, while Angelina Jolie's 2013 double mastectomy raised public awareness of BRCA mutations.
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The Independent broke the news in London, United Kingdom on Monday, September 29, 2025.
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