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NFL Week 2 Schedule, Predictions and More
C.J. Stroud faces a Bengals defense that forced four fumbles in Week 1, while Houston enters after scoring 98 combined points between both teams.
On Monday, September 21, 2026, the NFL Week 2 slate begins as betting markets adjust following a record-setting Week 1. Analysts reassess team identities after 791 total points were scored across the league.
The 2026 season launched with 791 total points scored, tying an NFL record for an opening slate. Coaches and analysts now evaluate which early-season trends are sustainable versus statistical anomalies.
Chicago Bears momentum builds after scoring 59 points against the Panthers, while the Buffalo Bills host the Detroit Lions at Highmark Stadium on Thursday night. Both teams enter Week 2 with high offensive expectations.
Analysts favor the Houston Texans to rebound against the Cincinnati Bengals on Sunday. The New York Giants face the Los Angeles Rams on Monday Night Football after defeating the Dallas Cowboys in Week 1.
Survivor pool participants target the San Francisco 49ers as significant favorites against the Miami Dolphins in Week 2. Teams across the league strive to avoid 0-2 starts as volatile matchups unfold.