How Does DDIT4 Activation Prevent HIV Rebound?

How does DDIT4 activation prevent HIV rebound?

DDIT4 as a “lock” against HIV reactivation Researchers investigating why HIV can rebound after ART interruption report that metformin can help keep the virus dormant by activating a pathway involving the gene DDIT4. In the study’s framing, DDIT4 functions like a molecular “lock”: once engaged, it…

New study shows that the common diabetes drug metformin can keep HIV dormant by activating a "molecular lock" gene called DDIT4. By preventing the virus from reawakening, this discovery offers a new path toward long-term HIV remission without the need for