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New Inflammatory Pathway Found in RA, Explains Lack of Response to TNF Inhibitors
Summary by Inside Precision Medicine
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New Inflammatory Pathway Found in RA, Explains Lack of Response to TNF Inhibitors
Researchers at Washington State University have potentially found the reason why tumor necrosis factor inhibitors (TNFis) are an ineffective treatment in as many as 40% of patients with rheumatoid arthritis (RA), by identifying an alternate inflammatory signaling pathway that allows inflammation to persist even when TNF activity is blocked. The study, published in Cellular & Molecular Immunology, found that TNF-α can exploit signaling through th…
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