New brain atlas reveals insights into Huntington's, addiction, and other disorders
The atlas links distinct cell types to Huntington’s disease, addiction, depression and schizophrenia, and highlights limits of standard mouse models.
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5 Articles
Towards new therapies for Huntington and schizophrenia (ANSA)
New brain atlas reveals insights into Huntington's, addiction, and other disorders
A region of the brain called the striatum is critical for many cognitive and motor functions, including decision-making, control of movement, habit formation, and processing of reward.
Atlas of the brain's striatum could guide researchers to new drug treatments
A region of the brain called the striatum is critical for many cognitive and motor functions, including decision-making, movement control, habit formation and reward processing. It also plays a role in addiction and is significantly affected by Huntington's disease, schizophrenia and other disorders.
Single-Cell Striatum Atlas Reveals Neurological Disorder Vulnerabilities
Researchers generated a single-cell atlas of the striatum, identifying 31 neuronal subpopulations and disease-linked vulnerabilities that could inform studies of Huntington’s disease, schizophrenia, depression, and substance use disorder. The post Single-Cell Striatum Atlas Reveals Neurological Disorder Vulnerabilities appeared first on GEN - Genetic Engineering and Biotechnology News.
An atlas developed by MIT researchers identifies 31 neuronal subgroups of striate and shows why some cells are especially vulnerable to Huntington, while others are involved in addiction, depression, and schizophrenia. *** The team analyzed post-mortem human tissue and distinguished 31 neuronal subpopulations using various molecular and spatial techniques. Atypical neurons D1 and D2 showed links to substance disorders, antidepressants, and respo…
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