Mutation map shows how key cancer gene drives tumor growth

Mutation map shows how key cancer gene drives tumor growth

Scientists have created a complete map showing how hundreds of possible mutations in a key cancer gene influence tumor growth. The study focused on CTNNB1, a gene that produces the protein β-catenin, which helps regulate tissue growth and repair. When β-catenin is disrupted, cells can begin uncontrolled growth—a hallmark of cancer. The work is published in Nature Genetics.

Mutation Map Indicates How Alterations in Key Cancer Gene Influence Tumor Growth

An international team of scientists headed by researchers at the University of Edinburgh, has created a complete map showing how hundreds of possible mutations in a key cancer gene, CTNNB1, influence tumor growth. CTNNB1 is the gene coding for the protein β-catenin, which helps regulate tissue growth and repair. When β-catenin is disrupted, cells can begin uncontrolled growth—a hallmark of cancer. By systematically testing all possible mutations…

New map reveals cancer mutation effects | News | The University of Edinburgh

New map reveals cancer mutation effects gatkinso Mon, 02/02/2026 - 10:39 Scientists have created a complete map showing how hundreds of possible mutations in a key cancer gene influence tumour growth. The study focused on CTNNB1, a gene that produces the protein β-catenin, which helps regulate tissue growth and repair. When β-catenin is disrupted, cells can begin uncontrolled growth – a hallmark of cancer.By systematically testing all possible …