LRP8 is a receptor for tick-borne encephalitis virus

LRP8 is a receptor for tick-borne encephalitis virus

Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe and sometimes life-threatening disease characterized by viral invasion of the central nervous system with symptoms of neuroinflammation1,2. As with other orthoflaviviruses—enveloped, arthropod-borne RNA viruses—host factors required for TBEV entry remain poorly defined. Here we used a genome-scale CRISPR–Cas9-based screen to identify LRP8, an apolipoprotein E and…

LRP8 Identified as Tick-Borne Encephalitis Receptor

In a groundbreaking study that promises to reshape our understanding of tick-borne encephalitis virus (TBEV) neuropathogenesis, scientists have identified a pivotal host receptor that facilitates viral entry into human cells. TBEV is recognized as a formidable neurotropic pathogen responsible for tick-borne encephalitis (TBE), a severe neurological disease characterized by viral infiltration of the central nervous […]