Published 1 day ago • loading... • Updated 12 hours ago

Lions vs. Bills prediction, odds: 'Thursday Night Football' picks from proven model

The SportsLine projection model has revealed its Detroit vs. Buffalo picks for NFL Week 2 on Thursday, Sept. 17 as Highmark Stadium hosts its first regular-season game

Podcasts & Opinions

Podcast Mention

The Herd with Colin Cowherd

Daily Sports podcast from The Herd with Colin Cowherd

BEST OF THE HERD – New Era For Josh Allen & Bills | Caleb Williams Is A Playmaker | Jalen Hurts Gets Too Much Criticism

The Herd with Colin Cowherd discuss Bills–Lions Thursday Night Football, Buffalo’s new stadium debut, and Josh Allen’s bid for a breakthrough season

10 hours ago

Listen to Full Episode Full Episode Unlock Timestamp

Get Vantage — Podcasts, Ratings, Timestamps

Podcasts & Opinions

5 Articles

NBC Sports

Center

Bills vs Lions Odds, expert picks, team and player news, betting trends, and stats

Buffalo Bills vs Detroit Lions Game Preview

12 hours ago·Stamford, United States

Read Full Article

Sports Illustrated

Lean Left

Lions vs. Bills Score Prediction for NFL Week 2 (Expect a Ton of Points on Thursday Night)

Using the latest odds and analysis to predict the final score of the Detroit Lions-Buffalo Bills matchup in Week 2 of the NFL season.

19 hours ago·New York, United States

Read Full Article

CBS Sports

Center

Lions vs. Bills prediction, odds: 'Thursday Night Football' picks from proven model

The SportsLine projection model has revealed its Detroit vs. Buffalo picks for NFL Week 2 on Thursday, Sept. 17 as Highmark Stadium hosts its first regular-season game

1 day ago·Fort Lauderdale, United States

Read Full Article

USA Today

Reposted by

AZCentral

Lean Left

Lions vs Bills odds, point spread, moneyline, total for game Thursday

Buffalo Bills vs Detroit Lions odds for NFL Week 2 game betting, including point spread, moneyline, over/under, total for Thursday, Sept. 17, 2026.

2 days ago·New York, United States

Read Full Article

Think freely.Subscribe and get full access to Ground NewsSubscriptions start at $9.99/year

Coverage Details

Total News Sources5

Leaning Left3Leaning Right0Center2Last Updated12 hours agoBias Distribution

60% Left

Bias Distribution

60% of the sources lean Left

60% Left

Factuality

To view factuality data please Upgrade to Premium

Ownership

To view ownership data please Upgrade to Vantage

USA Today broke the news in New York, United States 2 days ago on Wednesday, September 16, 2026.

Sources are mostly out of (0)

Lions vs. Bills prediction, odds: 'Thursday Night Football' picks from proven model

The Herd with Colin Cowherd

5 Articles

5 Articles

Bills vs Lions Odds, expert picks, team and player news, betting trends, and stats

Lions vs. Bills Score Prediction for NFL Week 2 (Expect a Ton of Points on Thursday Night)

Lions vs. Bills prediction, odds: 'Thursday Night Football' picks from proven model

Lions vs Bills odds, point spread, moneyline, total for game Thursday

Coverage Details

Bias Distribution

Factuality

Ownership

More stories like this

Lions Quickly Turning Page to High-Tempo Bills' Offense

Frustrated Dan Campbell Makes Expletive Statement As Bills Put Up Nearly 30 Points at Halftime Against Lions

Josh Allen Pulls a Wild Move on the Sideline During His Monster 4-TD Half

Josh Allen Christens Buffalo Bills’ New Stadium with 5-TD Outing in 41-31 Win over Detroit Lions

Lions rule out starting offensive linemen Blake Miller and Christian Mahogany against Bills

Lions Face Early Season Test Under the Lights in Buffalo

Similar News Topics

Similar News Topics

The Herd with Colin Cowherd

More stories like this

Lions Quickly Turning Page to High-Tempo Bills' Offense

Frustrated Dan Campbell Makes Expletive Statement As Bills Put Up Nearly 30 Points at Halftime Against Lions

Josh Allen Pulls a Wild Move on the Sideline During His Monster 4-TD Half

Josh Allen Christens Buffalo Bills’ New Stadium with 5-TD Outing in 41-31 Win over Detroit Lions

Lions rule out starting offensive linemen Blake Miller and Christian Mahogany against Bills

Lions Face Early Season Test Under the Lights in Buffalo

Lions vs. Bills prediction, odds: 'Thursday Night Football' picks from proven model

The model projects 58 combined points and says the Over has value in 57% of simulations.

The Herd with Colin Cowherd

5 Articles

5 Articles

Bills vs Lions Odds, expert picks, team and player news, betting trends, and stats

Lions vs. Bills Score Prediction for NFL Week 2 (Expect a Ton of Points on Thursday Night)

Lions vs. Bills prediction, odds: 'Thursday Night Football' picks from proven model

Lions vs Bills odds, point spread, moneyline, total for game Thursday

Coverage Details

Bias Distribution Too Big Arrow Icon

Factuality Info Icon

Ownership

More stories like this

Lions Quickly Turning Page to High-Tempo Bills' Offense

Frustrated Dan Campbell Makes Expletive Statement As Bills Put Up Nearly 30 Points at Halftime Against Lions

Josh Allen Pulls a Wild Move on the Sideline During His Monster 4-TD Half

Josh Allen Christens Buffalo Bills’ New Stadium with 5-TD Outing in 41-31 Win over Detroit Lions

Lions rule out starting offensive linemen Blake Miller and Christian Mahogany against Bills

Lions Face Early Season Test Under the Lights in Buffalo

Similar News Topics

Similar News Topics

The Herd with Colin Cowherd

More stories like this

Lions Quickly Turning Page to High-Tempo Bills' Offense

Frustrated Dan Campbell Makes Expletive Statement As Bills Put Up Nearly 30 Points at Halftime Against Lions

Josh Allen Pulls a Wild Move on the Sideline During His Monster 4-TD Half

Josh Allen Christens Buffalo Bills’ New Stadium with 5-TD Outing in 41-31 Win over Detroit Lions

Lions rule out starting offensive linemen Blake Miller and Christian Mahogany against Bills

Lions Face Early Season Test Under the Lights in Buffalo

Bias Distribution

Factuality