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Hidden Bacterial Molecules in the Brain Reveal New Secrets of Sleep

Researchers at Washington State University found bacterial molecules in mouse brains that fluctuate with sleep cycles, supporting a model where microbes help regulate sleep, the study shows.

Summary by Science Daily
New studies show that a bacterial molecule, peptidoglycan, is present in the brain and fluctuates with sleep patterns. This challenges the idea that sleep is solely brain-driven, instead suggesting it’s a collaborative process between our bodies and microbiomes. The theory links microbes not only to sleep but also to cognition, appetite, and behavior, pointing to a profound evolutionary relationship.

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Scientists have revealed that sleep arises from communication between the regulatory systems of the body, the brain and the multitude of microbes that live within us, especially the intestinal microbiota.

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Medical Xpress broke the news in on Wednesday, September 24, 2025.
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