New ROOT Method Charts a Path to Reversing Biological Changes Once Thought Irreversible

New ROOT method charts a path to reversing biological changes once thought irreversible

Once a cell has locked into an abnormal state—the way cancer cells do—can it ever be restored to normal? A KAIST research team led by Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering has, for the first time, identified the causal circuits responsible for irreversibility in intracellular molecular networks and developed a fundamental control technology called ROOT that can regulate these circuits and restore biological states to their original conditions.

KAIST research opens new path toward releasing 'molecular lock' and reversing cell's fate

Once a cell has locked into an abnormal state — the way cancer cells do — can it ever be restored back to normal? A KAIST research team has identified the 'molecular lock' that keeps cells trapped in an altered state, opening a new path toward releasing that lock and reversing a cell's fate.

KAIST develops technology reversing irreversible biological changes,

A cell that has become cancerous, aged or otherwise abnormal may appear to have crossed a biological point of no return. Once its internal molecular circuitry has stabilized in a new state, removing the original trigger often does not restore the cell to normal. Now, researchers at the Korea Advanced Institute of Science and Technology […]

New method could reverse abnormal cell states linked to aging and cancer

Researchers identified molecular circuits that lock cells into abnormal states and developed a way to reset them, opening new possibilities for aging and cancer research.