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JCI Neurodegeneration biomarkers in Alzheimer’s disease: axonal density index expands the “N” in the AT(N) framework

Summary by jci.org
Neurodegeneration, along with amyloid and tau, define the AT(N) framework of Alzheimer’s disease that has shaped the development of diagnostics and therapeutics. Yet, biomarker development for neurodegeneration has lagged behind that for amyloid and tau, with limited definition of its heterogeneous microstructural aspects that may each serve as critical measures. In this issue of the JCI, Gong et al. leveraged diffusion MRI to derive a unique me…
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jci.org broke the news in on Monday, February 2, 2026.
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