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JCI Insight High tumor mutational burden and PIK3CA mutations correlate with poor Merkel cell carcinoma–specific survival
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JCI Insight High tumor mutational burden and PIK3CA mutations correlate with poor Merkel cell carcinoma–specific survival
Merkel cell carcinoma (MCC) is a neuroendocrine carcinoma of the skin characterized by poor prognosis. This study aimed to explore the relationship between genetic alterations, tumor mutational burden (TMB), and MCC-specific survival (MCC-SS) in patients who underwent genomic profiling of tumors with OncoPanel. Univariate and multivariable analysis were used to assess the impact of genetic alterations on MCC-SS. Of the 188 identified patients, 1…
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