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JCI Breaking down to rebuild: lymphatic ablation enhances osteoclast-driven regeneration
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JCI Breaking down to rebuild: lymphatic ablation enhances osteoclast-driven regeneration
The fingertip is one of the only known complex structures in mammals that can fully regenerate following amputation. This phenomenon can be studied in mice using the amputation of the digit tip, the regenerative success of which has been shown to be reliant on effective bone clearance prior to new bone formation. In this issue of the JCI, Vishlaghi et al. investigated whether local lymphatic vessels are involved in this process. Interestingly, t…
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