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Indianapolis Colts V. Kansas City Chiefs Preview, Key Matchups And Prediction - Last Word On NFL

Most analysts expect Kansas City to cover a 6.5-point spread after the Chiefs opened with a strong defensive showing and the Colts struggled in Week 1.

The Indianapolis Colts and Kansas City Chiefs will meet in a Sunday Night Football matchup at Arrowhead this weekend. Here's a preview of the key matchups and a final score prediction.

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Indy Star broke the news in Indianapolis, United States on Friday, September 18, 2026.
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