Impairment of Glymphatic Cerebrospinal Fluid Drainage is a Feature of Cerebral Small Vessel Disease

Impairment of Glymphatic Cerebrospinal Fluid Drainage is a Feature of Cerebral Small Vessel Disease

The glymphatic system parallels blood vessels where they enter the brain, providing a path for drainage of cerebrospinal fluid from the brain into the body. The other well described path is through channels in the cribriform plate bone. These drainage routes become dysfunctional with age, allowing metabolic waste to build up in the brain, and thus contributing to the dysfunctional environment that causes pathology and neurodegeneration. An appro…