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Betel Nut Sucking Is the Earliest Recorded Evidence for the Habitual Use of a Neuroactive Plant Drug

Biochemical tests found arecoline in two ancient teeth, giving direct evidence that Sulawesi foragers used betel nut as a stimulant.

  • Griffith University researchers discovered evidence that hunter-foragers in Sulawesi, Indonesia, were using betel nut as a psychoactive drug as far back as 25,000 years ago, pushing the known history of human drug use into the Ice Age.
  • Previously, scientists believed habitual drug use emerged only after the Neolithic advent of farming, with fermented drinks appearing about 13,000 years ago; this finding suggests modern drug-taking behaviors are deeply rooted in forager traditions.
  • Researchers identified deep, rounded tooth grooves in skeletal remains of two individuals dated to 25,000-16,000 and 7,600-6,300 years ago; biochemical testing confirmed arecoline in their dental tissues, providing physical evidence of habitual betel nut consumption.
  • Prolonged nut-sucking severely damaged the foragers' teeth, exposing pulp chambers and causing chronic infection; the resulting pain may have paradoxically compelled them to continue the damaging habit, creating a cycle of drug dependence.
  • Professor Adam Brumm, who led the study, identified this as the "earliest evidence for drug use anywhere in the world"; today, betel nut remains the world's fourth most widely used psychoactive substance, consumed by about one in 10 people globally.
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Ancient human remains in Indonesia show evidence of habitual betel nut use

·Ankara, Türkiye
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Early inhabitants of Indonesia already used betel nuts – also to numb toothache, Australian researchers say. However, this apparently further damaged the teeth.

·Vienna, Austria
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Phys.org broke the news in Douglas, United Kingdom on Wednesday, September 9, 2026.
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