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GLP-1 drugmakers sued over sudden vision loss risk: Reports
Dozens of plaintiffs say the drugs caused NAION, and one study found 35 cases among more than 159,000 patients.
Dozens of patients have filed Lawsuits against drugmakers Novo and Eli Lilly, alleging the companies failed to warn users about sudden vision loss from GLP-1s including Ozempic, Wegovy, Mounjaro, and Zepbound.
Non-Arteritic anterior ischaemic optic neuropathy, or NAION, is a rare condition that can lead to sudden and sometimes permanent vision loss due to lack of blood flow to the optic nerve.
Research involving more than 159,000 participants with type 2 diabetes found 35 cases of NAION among GLP-1 users compared to 19 in the comparison group; researchers also identified 93 patients with 'Other optic nerve disorders.'
Similar Lawsuits against Eli Lilly are currently pending, with plaintiffs claiming the company failed to adequately warn patients of risks associated with their weight-loss and diabetes treatments.
The American Academy of Ophthalmology encourages clinicians and patients to make 'informed choices' regarding GLP-1s, while noting that studies show modest risk but fewer patients experienced sight-threatening complications from diabetes.