FR-Alpha-Positive Ovarian Cancer What Is FR-Alpha–Positive Ovarian Cancer? FR-alpha–positive ovarian cancer means the tumor cells have high levels of the FR-alpha protein (called a biomarker) on their surface.e60dc2a1-f33c-4a05-9b50-8e3e8e597629f6cdabf7-7bac-4202-a8f3-9c552af95859 This protein helps cells absorb folate, a vitamin they use to grow and divide.e60dc2a1-f33c-4a05-9b50-8e3e8e597629b76bb457-98c5-4385-a7d4-8373af153591 While healthy …