Scientists Create the First Detailed 'Smell Map' of Odor Sensors in the Mouse Nose—and Sniff Out Some Surprises
The map shows 1,100 receptor types form overlapping stripes in mouse noses and matches smell maps in the brain, researchers said.
- On Tuesday, April 28, 2026, Harvard Medical School professor Sandeep Datta and colleagues published findings in Cell revealing that mouse smell receptors form precise horizontal stripes, mapping over 1,100 receptor types.
- For 30 years, researchers taught that mouse olfactory receptor choice was essentially random within broad zones; Johan Lundstr, a neuroscientist at the Karolinska Institute, noted this study overturns that foundational model.
- Using single-cell sequencing and spatial transcriptomics, the team analyzed 5.5 million neurons across more than 300 mice, pinpointing the exact spatial location of each receptor type within the nasal cavity.
- Researchers confirmed the nasal spatial map corresponds directly with "smell maps" in the brain's olfactory bulb, where a gradient of retinoic acid guides each neuron to express the correct receptor based on its "latitude."
- These findings could support future therapies for anosmia, a condition linked to depression and safety risks, as Datta aims to translate the receptor map to human tissue and determine the precise band order.
37 Articles
37 Articles
A hidden map in your nose could explain how smell works
Scientists have finally cracked one of the biggest mysteries in the senses: how smell is organized. By mapping millions of neurons in mice, researchers discovered that smell receptors in the nose aren’t random at all—they’re arranged in neat, overlapping stripes based on receptor type, forming a hidden structure scientists never knew existed. Even more striking, this layout mirrors how smell information is mapped in the brain, revealing a coordi…
Scientists Create the First Detailed 'Smell Map' of Odor Sensors in the Mouse Nose—and Sniff Out Some Surprises
In two new studies, researchers used genetic techniques to upend a long-standing assumption that the nerve cells with scent detectors were randomly arranged. They don’t know whether the same spatial organization is found in human noses
First-Ever “Smell Map” Illustrates Just How Little We Knew About Our Noses
It has been said that human beings can distinguish and mentally catalog more than 10,000 distinct scents, and yet despite the acuity of our noses, smell itself remains our least understood and least well-explained human sense. We have long known that the walls of our nasal cavity–aka, our noses–are lined with millions of tiny olfactory receptors, nerves that emit signals to our brain. The “olfactory bulb” deep in our brain makes sense of these s…
First detailed ‘smell maps’ reveal how noses track odours
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Harvard scientists create first detailed map of smell receptors
For most of us, the sense of smell is an integral part of everyday life; it plays a critical role in providing information about our surroundings, alerting us to potential dangers, enhancing our sense of taste, and evoking emotions and memories.
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