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Extended-Release Buprenorphine Linked to Higher Opioid Abstinence in Pregnancy Than Daily Treatment

Summary by APF
A randomized clinical trial published in JAMA Internal Medicine found that weekly extended-release buprenorphine during pregnancy was associated with higher rates of abstinence from illicit opioids than daily sublingual buprenorphine among pregnant women with opioid use disorder. Overall maternal and infant outcomes were similar between groups. However, the extended-release buprenorphine group reported fewer serious adverse events, less use of p…
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APF broke the news in on Friday, March 20, 2026.
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