DNA-editing ‘pencils’ probe early human development

New base editing techniques accurately modify genes in human embryos

A study by researchers at Columbia University Vagelos College of Physicians and Surgeons has found that new cutting-edge techniques can accurately edit genes in human embryos-giving scientists indispensable tools for understanding normal human development-but has also uncovered important risks that currently preclude the use of the techniques in the clinic.

DNA-editing ‘pencils’ probe early human development

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02840-7A genome-rewriting approach known as adenine base editing offers a precise way to investigate gene function in early human embryos.

Advanced Gene Editing Provides Essential Tool for Studying Early Human Embryonic Development

A study by researchers at Columbia University Vagelos College of Physicians and Surgeons has found that new cutting-edge techniques can accurately edit genes in human embryos-giving scientists indispensable tools for understanding normal human development-but has also uncovered important risks that currently preclude the use of the techniques in the clinic.

Study shows limits of 'precise' gene editing in human embryos

New cutting-edge techniques can accurately edit genes in human embryos—giving scientists indispensable tools for understanding normal human development—but come with important risks.