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Development and characterization of orally disintegrating films of Nebivolol as complex with Sulfobutylether-β-cyclodextrin
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1 Articles
Development and characterization of orally disintegrating films of Nebivolol as complex with Sulfobutylether-β-cyclodextrin
Abstract Low water solubility and extensive hepatic first-pass metabolism limit oral bioavailability of Nebivolol hydrochloride (NEB), a new-generation β-blocker agent effective in hypertension treatment. To overcome such issues, a combined strategy was applied, based on the development of orally disintegrating films (ODFs) loaded with NEB as SBEβCD complex. This approach exploits both the SBEβCD solubilizing power and the fast drug dissolution …
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