CRISPR-Enhanced CAR T Cell Therapies Unveiled

Systematic Discovery of CRISPR-Boosted CAR T Cell Immunotherapies

Scientists performed genome-wide screens in human primary CAR T cells, with readouts capturing key aspects of T cell biology, including proliferation, target cell recognition, activation, apoptosis and fratricide, and exhaustion. [Nature] Full Article

CRISPR-Enhanced CAR T Cell Therapies Unveiled

A groundbreaking study published in Nature reveals a transformative approach to boosting the efficacy of CAR T cell therapies through targeted gene knockouts enabled by CRISPR technology. Researchers systematically identified and validated specific gene knockouts that significantly enhance the cancer-fighting potential of CAR T cells, the engineered immune cells that have revolutionized treatment for certain […]