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Citraconate Enhances Antitumor Activity and Reduces Exhaustion in T Cells
Summary by Inside Precision Medicine
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Citraconate Enhances Antitumor Activity and Reduces Exhaustion in T Cells
Researchers have found a novel therapeutic target to enhance the effects of cancer immunotherapy. A study published today in Science Immunology reveals how a metabolite known as citraconate can reduce T cell exhaustion and enhance the ability of these immune cells to live longer, multiply, and effectively fight tumors. Despite the widespread success of checkpoint inhibitor immunotherapies, a substantial proportion of patients still do not respo…
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