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Smallpox DNA is recovered from Spanish conquest-era Chilean mummies

Genetic analysis linked the mummies’ virus to an extinct lineage between medieval European strains and later variants, strengthening evidence that colonizers brought smallpox to the Americas.

  • Researchers at Trinity College Dublin identified the oldest viral smallpox DNA in the Americas from two Chilean mummies, providing the first direct molecular evidence of the pathogen in the region.
  • Smallpox decimated Indigenous populations after European colonizers arrived in the Americas during the late 15th century, with the mummies dated to between 1492 and 1631.
  • Molecular analysis indicates the strains existed in a now-extinct variola virus lineage bridging Old World European variants and later types, with genetic deceleration during colonial expansion.
  • This discovery provides the first molecular confirmation that smallpox was carried to the Americas during the colonial period, proving Europe directly introduced the virus to Indigenous populations.
  • Evidence helps clarify how the virus reached remote regions, as written records for Chile begin significantly later than the colonial era, filling a critical historical gap.
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Lean Right

Ancient DNA confirms European colonizers brought smallpox to Americas

Until now, there had been no direct genetic evidence linking colonial-era outbreaks in the Americas to strains circulating in the Old World.

·Lenoir, United States
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Lean Left

Millions of indigenous people died in America during the colonial period as a result of introduced diseases. Researchers have now confirmed by genetic analysis: smallpox also came from Europe.

·Hamburg, Germany
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Lean Right

A study published in Science recovered the oldest smallpox genomes found in America and provided the strongest evidence so far that the disease reached the continent during European colonization.

·Vicente López, Argentina
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Science broke the news in Washington, United States on Thursday, July 30, 2026.
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