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Global Deaths, Disability From Heart Disease Continue to Rise Sharply

Nearly 80% of cardiovascular disease burden in 2023 was due to modifiable risk factors, with 19.2 million deaths marking a significant rise since 1990, researchers said.

  • On September 24, 2025, the Global Burden of Disease Study published in JACC found cardiovascular diseases caused one in three global deaths, totaling 19.2 million in 2023.
  • Researchers attributed the rise to population growth and population aging, while modifiable risk factors like high body mass index and high fasting plasma glucose are increasing, fueling the trend.
  • Global DALY figures show that 437 million CVD DALYs were recorded in 2023, a 1.4-fold increase from 320 million in 1990, with ischemic heart disease affecting 240 million people and a 16-fold country disparity.
  • JACC Editor-in-Chief Harlan Krumholz warned, `This report is a wake-up call: Heart disease remains the world's leading cause of death, and the burden is rising fastest in places least equipped to bear it,` urging action to save millions.
  • With nearly 80% of CVD DALYs linked to modifiable risks, the report presented at the 80th Session of the United Nations General Assembly urges national health agencies to act in the coming years.
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Heart Disease Remains Top Killer Worldwide

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Considered the first cause of death in the world, it is cardiovascular disease, understood as the malfunction of the heart, its blood vessels, formation of clots and other organ failures that is responsible for oxygenating and pumping...

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Medical Xpress broke the news in on Wednesday, September 24, 2025.
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